Uric acid levels in metabolically healthy and unhealthy obese patients

The metabolome profiling of obese and non-obese individuals: Metabolically healthy obese and unhealthy non-obese paradox

Objective(s): The molecular basis of “metabolically healthy obese” and “metabolically unhealthy non-obese” phenotypes is not fully understood. Our objective was to identify metabolite patterns differing in obese (metabolically healthy vs unhealthy (MHO vs MUHO)) and non-obese (metabolically healthy vs unhealthy (MHNO vs MUHNO)) individuals. Materials ...

Evaluation of Serum Uric Acid and Glutathione Levels in Diabetic Patients and Healthy Subjects

Objective: It is well known that diabetes is one of the main health challenges. According to the evidence presented in recent years by investigators, serum uric acid has emerged as a possible risk factor for diabetes mellitus. The aim of the present study was to compare the mean serum uric acid and the antioxidant activity of glutathione levels in patients with diabetes and the control group. ...

Heart disease risk among metabolically healthy obese men and metabolically unhealthy lean men.

Prevalence, Risk Factors, and Genetic Traits in Metabolically Healthy and Unhealthy Obese Individuals

OBJECTIVE To assess prevalence of metabolically healthy individuals among patients with abdominal obesity (AO) and to determine phenotype and potential genetic traits associated with a benign metabolic status. METHODS 503 AO patients without cardiovascular diseases were examined. Waist circumference (WC), BMI, blood pressure, plasma glucose and serum insulin levels, HOMA-IR, lipid profile, an...

Preclinical Systolic and Diastolic Dysfunctions in Metabolically Healthy and Unhealthy Obese Individuals.

BACKGROUND Despite the substantial overlap of obesity and metabolic disease, there is heterogeneity with respect to cardiovascular risk. We sought to investigate preclinical differences in systolic and diastolic function in obesity, and specifically compare obese individuals with and without metabolic syndrome (MS). METHODS AND RESULTS Obese individuals without cardiac disease with (OB/MS+, n...